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・ Adenozil-chloride synthase
・ Adenstedt
・ Adenta
・ Adenta (Ghana parliament constituency)
・ Adenta East
・ Adenta Municipal District
・ Adentro
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・ Adenylate dimethylallyltransferase
・ Adenylate kinase
・ Adenylosuccinate
・ Adenylosuccinate lyase
・ Adenylosuccinate lyase deficiency
・ Adenylosuccinate synthase
Adenylyl cyclase
・ Adenylyl-(glutamate—ammonia ligase) hydrolase
・ Adenylyl-sulfate kinase
・ Adenylyl-sulfate reductase
・ Adenylyl-sulfate reductase (glutathione)
・ Adenylyl-sulfate reductase (thioredoxin)
・ Adenylylation
・ Adenylylsulfatase
・ Adenylylsulfate—ammonia adenylyltransferase
・ Adenylyltransferase and sulfurtransferase MOCS3
・ Adenzai
・ Adenízia da Silva
・ Adeo Ressi
・ Adeodato Barreto
・ Adeodato Giovanni Piazza


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Adenylyl cyclase : ウィキペディア英語版
Adenylyl cyclase

Adenylyl cyclase (, also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known AC class is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues.
All classes of AC catalyze the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. Magnesium ions are generally required and appears to be closely involved in the enzymatic mechanism. The cAMP produced by AC then serves as a regulatory signal via specific cAMP-binding proteins, either transcription factors or other enzymes (e.g., cAMP-dependent kinases).
==Class I AC==
Class I AC's occur in many bacteria including ''E. coli''. This was the first class of AC to be characterized. It was observed that ''E. coli'' deprived of glucose produce cAMP that serves as an internal signal to activate expression of genes for importing and metabolizing other sugars. cAMP exerts this effect by binding the transcription factor CRP, also known as CAP. Class I AC's are large cytosolic enzymes (~100 kDa) with a large regulatory domain (~50 kDa) that indirectly senses glucose levels. , no crystal structure is available for class I AC.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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